Adenocarcinoma of the jejunum associated with nontropical sprue

  title={Adenocarcinoma of the jejunum associated with nontropical sprue},
  author={Edward P. Petreshock and Marius Pessah and Eliyahu Menachemi},
  journal={The American Journal of Digestive Diseases},
SummaryA patient with a thirty-year history of celiac disease, developed malabsorption and ultimately intestinal obstruction. He failed to respond to a strict gluten-free diet, steroids, and antibiotics. Postmortem examination revealed primary adenocarcinoma of the small bowel. The relationship between adenocarcinoma of the jejunum and celiac disease is reviewed. 
Duodenal adenocarcinoma complicating celiac sprue
This case illustrates the unmasking of subclinical celiac Sprue following upper gastrointestinal tract surgery and may also reflect the association between celiac sprue and malignancy.
A Challenging Diagnosis of Jejunal Adenocarcinoma in a Celiac Patient: Case Report and Systematic Review of the Literature.
A case of a challenging diagnosis of small bowel adenocarcinoma which developed in a patient with CD discovered only in the elderly is described and a tailored follow-up in a sub-group of CD patients at an increased risk of developing intestinal adenOCarcinomas could be implemented.


Primary carcinoma of the jejunum with atrophic jejunitis and intestinal malabsorption.
Summary A case of primary carcinoma of the jejunum in a male patient aged 72 years is reported, in which microscopy of the jejunum revealed atrophic jejunitis, and the presence of intestinal
Jejunal adenocarcinoma in a woman with nontropical sprue.
Summary In a 49-year-old woman with the history of nontropical sprue since age 20 there was found a circumscribed, slightly stenosing adenocarcinorna of the jejunum which was removed by radical
Coeliac disease and malignancy.
Studies of small-bowel epithelial-cell turnover have been performed on 18 cases who had been diagnosed as having adult ‘coeliac disease’ and the association of subtotal villous atrophy with a lower cell turnover seems to carry a particularly grave prognosis.
Multiple jejunal biopsies in adult celiac disease
Using a multiple jejunal biopsy capsule, 151 specimens were obtained from 40 patients with adult celiac disease, finding differences in the duodenum and jejunum are encountered sufficiently often to warrant multiple biopsies.
Adult coeliac disease
It is suggested that there is an underlying constitutional defect, not yet clearly defined, and that possibly secondary intestinal infection allows the intestinal mucosa to become sensitized to substances in the diet.
Coexistence of adenocarcinoma of the jejunum and nontropical sprue.
The following case is the first in which this combination of adenocarcinoma of the jejunum and nontropical sprue was observed at the Mayo Clinic and is also the third to appear in the literature.
Malignancy in adult coeliac disease and idiopathic steatorrhoea.
Evidence is given that both of these disorders can be complicated by malignancy, either lymphoma or carcinoma of the gastrointestinal tract (especially of the oesophagus), and a gluten-free diet appeared to decrease the risk of malignant complication.
Nature of the mucosal changes associated with malignant neoplasms in the small intestine.
It is felt that malignant disease, and particularly small bowel lymphoma, can produce a mucosal abnormality similar to that found in idiopathic steatorrhoea.
Histopathologic studies in steatorrhea.
Small intestinal villous atrophy was found in all of 23 cases with primary or idiopathic steatorrhea, including 1 patient with celiac disease, and was irreversible by treatment with folic acid, vitamin B 12, gluten-free diet, antibiotics, or cortisone.
The onset of a cœliac syndrome in middle age clearly indicates the need to search diligently for a lymphoma, and may require exploratory laparotomy and a careful follow-up for several years when no certain pathogenesis is provided by the initial investigation.