Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle.

@article{PenaudBudloo2008AdenoassociatedVV,
  title={Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle.},
  author={Magalie Penaud-Budloo and Caroline Le Guiner and Ali Nowrouzi and Alice Toromanoff and Yan Ch{\'e}rel and Pierre Chenuaud and Manfred Schmidt and Christof von Kalle and Fabienne Rolling and Philippe Moullier and Richard O. Snyder},
  journal={Journal of virology},
  year={2008},
  volume={82 16},
  pages={7875-85}
}
Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression following administration to skeletal muscle. In rodent muscle, the vector genomes persist in the nucleus in concatemeric episomal forms. Here, we demonstrate with nonhuman primates that rAAV vectors integrate inefficiently into the chromosomes of myocytes and reside predominantly as episomal monomeric and concatemeric circles. The episomal rAAV genomes assimilate into chromatin with a typical… CONTINUE READING

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