Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport.

@article{Castle2014AdenoassociatedVS,
  title={Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport.},
  author={Michael J Castle and Zachary T Gershenson and April R Giles and Erika L. F. Holzbaur and John N H Wolfe},
  journal={Human gene therapy},
  year={2014},
  volume={25 8},
  pages={705-20}
}
Adeno-associated virus (AAV) vectors often undergo long-distance axonal transport after brain injection. This leads to transduction of brain regions distal to the injection site, although the extent of axonal transport and distal transduction varies widely among AAV serotypes. The mechanisms driving this variability are poorly understood. This is a critical problem for applications that require focal gene expression within a specific brain region, and also impedes the utilization of vector… CONTINUE READING