Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates

@article{Zhou1998AdenoassociatedVD,
  title={Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates},
  author={S Z Zhou and JE Murphy and Jaime A. Escobedo and V J Dwarki},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={665-670}
}
Recombinant adeno-associated virus encoding the monkey erythropoietin gene (rAAV-cm-Epo) was generated and tested for its potential to confer long-term expression of the gene product following intramuscular injection. A single intramuscular injection of 2 × 1012 rAAV-cm-Epo particles into two baboons led to sustained high circulating Epo levels and a concomitant increase in hematocrit. The hematocrits reached 62 and 75% by week 10 (from pre- injection values of 38 and 40%, respectively) and… Expand
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