Adeno-associated virus infection of murine fibroblasts with help provided by mouse adenovirus.

Abstract

Adeno-associated virus (AAV-2) replicates to high titers when host cells are coinfected with a helper virus. Here we analyzed the coinfection of AAV-2 and mouse adenovirus (MAV-1) in murine fibroblasts. We observed that AAV-2/MAV-1 coinfected NIH 3T3 cells produced approximately 10-40-fold less AAV-2 DNAse resistant particles than Hela cells. Levels of AAV… (More)
DOI: 10.1016/j.virol.2009.04.020

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