Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway.

@article{Nonnenmacher2011AdenoassociatedV2,
  title={Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway.},
  author={Mathieu E Nonnenmacher and T. E. Weber},
  journal={Cell host & microbe},
  year={2011},
  volume={10 6},
  pages={563-76}
}
Adeno-associated viruses (AAVs) are nonpathogenic, nonenveloped, single-stranded DNA viruses in development as gene therapy vectors. AAV internalization was postulated to proceed via a dynamin-dependent endocytic mechanism. Revisiting this, we find that infectious endocytosis of the prototypical AAV, AAV2, is independent of clathrin, caveolin, and dynamin. AAV2 infection is sensitive to EIPA, a fluid-phase uptake inhibitor, but is unaffected by Rac1 mutants or other macropinocytosis inhibitors… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…