Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice

@article{Schneider2007AdenoassociatedV,
  title={Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice},
  author={Miriam Schneider and Rainer Spanagel and Sheng-Jia Zhang and Hilmar Bading and Matthias Klugmann},
  journal={BMC Neuroscience},
  year={2007},
  volume={8},
  pages={105 - 105}
}
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) controls activity-dependent gene transcription by regulating the activity of the cyclic AMP response element binding protein (CREB). This signaling pathway is involved in gating emotional responses in the CNS but previous studies did not address the potential roles of CaMKIV in discrete brain regions. In the present study, we aimed at specifically dissecting the role of CaMKIV in the nucleus accumbens of adult mice. We used recombinant… CONTINUE READING
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