Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity.

@article{Xiao1997AdenoassociatedV,
  title={Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity.},
  author={Xiao Xiao and Thomas J. McCown and Juan Li and George R. Breese and A Leslie Morrow and Richard Jude Samulski},
  journal={Brain research},
  year={1997},
  volume={756 1-2},
  pages={76-83}
}
In the inferior colliculus, adeno-associated virus (AAV) vectors are capable of gene transfer and stable, long-term expression, but it remained to be shown if this in vivo gene transfer could alter focal seizure sensitivity in the inferior colliculus. Because GABA receptors directly modulate inferior collicular seizures, AAV vectors were constructed with a cytomegalovirus (CMV) promoter and a truncated, human GABA(A) alpha1 cDNA in both the sense and antisense orientations. Seven days after… CONTINUE READING

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