Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice.

@article{Shen2006AdenoassociatedVH,
  title={Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice.},
  author={Fanxia Shen and Hua Su and Yongfeng Fan and Yongmei Chen and Yiqian Zhu and Weizhong Liu and William L. Young and Guo-Yuan Yang},
  journal={Stroke},
  year={2006},
  volume={37 10},
  pages={2601-6}
}
BACKGROUND AND PURPOSE Exogenous delivery of vascular endothelial growth factor gene (VEGF) may provide a useful approach to the treatment of brain ischemia. We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection. METHODS Three groups (n=36) of mice received AAVH9-VEGF, AAVH9-lacZ, or saline injection. Five days after gene transfer, the mice underwent 45 minutes of transient middle cerebral artery occlusion (tMCAO) followed by 1 to 7 days… CONTINUE READING
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