Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice

@article{Shen2008AdenoassociatedVV,
  title={Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice},
  author={Fanxia Shen and Yanhong Fan and Hua Su and Y Zhu and Y Chen and Weizhong Liu and William L. Young and Guo-Yuan Yang},
  journal={Gene Therapy},
  year={2008},
  volume={15},
  pages={30-39}
}
Uncontrolled expression of vascular endothelial growth factor (VEGF) in vivo may cause unexpected side effects, such as brain hemangioma or tumor growth. Because hypoxia-inducible factor-1 (HIF-1) is upregulated during cerebral ischemia and regulates gene expression by binding to a cis-acting hypoxia-responsive element (HRE), we therefore used a novel HRE, originating in the 3′-end of the erythropoietin (Epo) gene, to control gene expression in the ischemic brain. A concatemer of nine copies… CONTINUE READING

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