Adeno-associated viral gene transfer of transforming growth factor-β1 to human mesenchymal stem cells improves cartilage repair

@article{Pagnotto2007AdenoassociatedVG,
  title={Adeno-associated viral gene transfer of transforming growth factor-β1 to human mesenchymal stem cells improves cartilage repair},
  author={Michael R. Pagnotto and Zhuo Wang and John C Karpie and Mario Ferretti and Xiao Xiao and Constance R. Chu},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={804-813}
}
Bone marrow cells are routinely accessed clinically for cartilage repair. This study was performed to determine whether adeno-associated virus (AAV) effectively transduces human bone marrow-derived mesenchymal stem cells (hMSC) in vitro, whether AAV infection interferes with hMSC chondrogenesis and whether AAV-transforming growth factor-beta-1 (TGF-β1)-transduced hMSC can improve cartilage repair in vivo. Adult hMSC were transduced with AAV-green fluorescent protein (GFP) or AAV-transforming… CONTINUE READING
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