Adenine nucleotides via activation of ATP-sensitive K+ channels modulate hypoxic response in rat pulmonary artery.

Abstract

We examined the role of ATP-sensitive K+ channels in hypoxic pulmonary vasoconstriction, using isolated rat pulmonary arterial rings. Isolated rat pulmonary arterial rings displayed a rapid contraction followed by relaxation under hypoxic conditions. The ATP-sensitive K+ channel blocker glibenclamide (concentration > 1 microM) or a hyperglycemic buffer (15… (More)

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@article{Shigemori1996AdenineNV, title={Adenine nucleotides via activation of ATP-sensitive K+ channels modulate hypoxic response in rat pulmonary artery.}, author={Kay Shigemori and T. Ishizaki and Satoko Matsukawa and Ayako Sakai and Teiko Nakai and Susumu Miyabo}, journal={The American journal of physiology}, year={1996}, volume={270 5 Pt 1}, pages={L803-9} }