Adenine nucleotide translocase family: four isoforms for apoptosis modulation in cancer

@article{Brenner2011AdenineNT,
  title={Adenine nucleotide translocase family: four isoforms for apoptosis modulation in cancer},
  author={Catherine Brenner and Kothandharaman Subramaniam and Claire Pertuiset and Shazib Pervaiz},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={883-895}
}
Mitochondria have important functions in mammalian cells as the energy powerhouse and integrators of the mitochondrial pathway of apoptosis. The adenine nucleotide translocase (ANT) is a family of proteins involved in cell death pathways that perform distinctly opposite functions to regulate cell fate decisions. On the one hand, ANT catalyzes the adenosine triphosphate export from the mitochondrial matrix to the intermembrane space with the concomitant import of ADP from the intermembrane space… CONTINUE READING
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