Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.

  title={Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.},
  author={M{\'o}nica Zamora and Meritxell Granell and Teresa Mampel and Octavi Vińas},
  journal={FEBS letters},
  volume={563 1-3},
Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis. Nothing is known, however, about the apoptotic activity of ANT3. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. Transient overexpression of ANT3 resulted, like ANT1, in apoptosis as shown by an increase in the sub-G1 fraction, annexin V staining, low DeltaPsi(m), and activation of caspases 9 and 3. Moreover, the apoptosis… CONTINUE READING
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