Adenine nucleotide metabolism and compartmentalization in isolated adult rat heart cells.

  title={Adenine nucleotide metabolism and compartmentalization in isolated adult rat heart cells.},
  author={Timothy P. Geisbuhler and Ruth A. Altschuld and Ronald W. Trewyn and A Z Ansel and K G Lamka and Gerald P. Brierley},
  journal={Circulation research},
  volume={54 5},
The metabolism and intracellular compartmentalization of adenine nucleotides in a preparation of adult rat heart myocytes showing good morphology, viability, and tolerance to calcium ion has been examined by high performance liquid chromatography. These myocytes contain an average of 23 nmol adenine nucleotide per milligram protein which is about 60% of the adenine nucleotide content of intact rat heart tissue. The loss of adenine nucleotide occurs during the incubation and washing steps that… CONTINUE READING


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