Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm.

@article{Vadnais2014AdenineNM,
  title={Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm.},
  author={Melissa L Vadnais and Wenlei Cao and Haig K Aghajanian and Lisa A Haig-Ladewig and Angel Lin and Osama Al-Alao and George L. Gerton},
  journal={Biology of reproduction},
  year={2014},
  volume={90 6},
  pages={128}
}
While most ATP, the main energy source driving sperm motility, is derived from glycolysis and oxidative phosphorylation, the metabolic demands of the cell require the efficient use of power stored in high-energy phosphate bonds. In times of high energy consumption, adenylate kinase (AK) scavenges one ATP molecule by transphosphorylation of two molecules of ADP, simultaneously yielding one molecule of AMP as a by-product. Either ATP or ADP supported motility of detergent-modeled cauda epididymal… CONTINUE READING
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