Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

@article{Iyer2016AdenineMI,
  title={Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification},
  author={Lakshminarayan M. Iyer and Dapeng Zhang and L. Aravind},
  journal={Bioessays},
  year={2016},
  volume={38},
  pages={27 - 40}
}
While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA, it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential epigenetic role across diverse eukaryotes with biological consequences, which are distinct and possibly even opposite to the well‐studied 5‐methylcytosine mark. Adenine methyltransferases appear to have been independently acquired by eukaryotes on at least 13 occasions from prokaryotic restriction‐modification and… 

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Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

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