Adenine formation from adenosine by mycoplasmas: adenosine phosphorylase activity.

@article{Hatanaka1975AdenineFF,
  title={Adenine formation from adenosine by mycoplasmas: adenosine phosphorylase activity.},
  author={Masakazu Hatanaka and R A Del Giudice and Cedric Long},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1975},
  volume={72 4},
  pages={1401-5}
}
Mammalian cells have enzymes to convert adenosine to inosine by deamination and inosine to hypoxanthine by phosphorolysis, but they do not possess the enzymes necessary to form the free base, adenine, from adenosine. Mycoplasmas grown in broth or in cell cultures can produce adenine from adenosine. This activity was detected in a variety of mycoplasmatales, and the enzyme was shown to be adenosine phosphorylase. Adenosine formation from adenine and ribose 1-phosphate, the reverse reaction of… CONTINUE READING

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