Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway

@article{Klpfer2004AdenineDF,
  title={Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway},
  author={Antje Kl{\"o}pfer and Anne Hasenj{\"a}ger and Claus Belka and Klaus Schulze-Osthoff and Bernd Doerken and Peter Ted Daniel},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={9408-9418}
}
The adenine deoxynucleosides cladribine (2CdA) and fludarabine (FAraA) are DNA-damaging agents that interfere with DNA repair and induce apoptosis in nonproliferating lymphoid cells. Although both drugs are clinically used for the treatment of indolent lymphoproliferative diseases, the pathways of apoptosis induction remain largely unknown. In the present work, we demonstrate that both drugs induce apoptosis independently of death receptor signaling but activate the mitochondrial cell death… CONTINUE READING