Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus.

@article{Perrillo2004AdefovirDA,
  title={Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus.},
  author={Robert P. Perrillo and Hie Won Hann and David R. Mutimer and Bernard Willems and Nancy Wai Yee Leung and William M. Lee and Alison Moorat and S D Gardner and Mary A Woessner and Eric T Bourne and Carol L. Brosgart and Eugene R Schiff},
  journal={Gastroenterology},
  year={2004},
  volume={126 1},
  pages={81-90}
}
BACKGROUND AND AIMS Prolonged lamivudine therapy is associated with treatment-resistant YMDD mutant hepatitis B virus (HBV). We evaluated the efficacy and safety of adding adefovir dipivoxil to lamivudine in 135 patients with chronic hepatitis B (CHB) and YMDD mutant HBV. METHODS Ninety-five patients with compensated CHB (group A) were randomized to adefovir 10 mg daily (n = 46) or placebo (n = 49) for 52 weeks while continuing treatment with lamivudine. Forty patients with decompensated… CONTINUE READING

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