Adducts between nucleophilic amino acids and hexahydrophthalic anhydride, a structure inducing both types I and IV allergy.

@article{Ahlfors2005AdductsBN,
  title={Adducts between nucleophilic amino acids and hexahydrophthalic anhydride, a structure inducing both types I and IV allergy.},
  author={Stefan R Ahlfors and Monica H Kristiansson and Christian Lindh and Bo A. G. J{\"o}nsson and C. Fredrik Hansson},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  year={2005},
  volume={10 5},
  pages={321-35}
}
Haptens causing type I allergy have been shown to predominantly form lysine adducts in the carrier protein, while many haptens giving rise to type IV allergy preferentially form adducts with cysteine residues. Hexahydrophthalic anhydride derivatives are strong sensitizers capable of inducing allergic rhinitis, asthma and urticaria (type I allergy) and allergic contact dermatitis (type IV allergy). The ability of hexahydrophthalic anhydride (HHPA) to form adducts with nucleophilic amino acids… CONTINUE READING

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