Addressing thrombogenicity in vascular graft construction.

@article{Sarkar2007AddressingTI,
  title={Addressing thrombogenicity in vascular graft construction.},
  author={Sandip Sarkar and Kevin M. Sales and George Heard Hamilton and Alexander M Seifalian},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2007},
  volume={82 1},
  pages={
          100-8
        }
}
Thrombosis is a major cause of poor patency in synthetic vascular grafts for small diameter vessel (< 6 mm) bypass. Arteries have a host of structural mechanisms by which they prevent triggering of platelet activation and the clotting cascade. Many of these are present in vascular endothelial cells. These mechanisms act together with perpetual feedback at different levels, providing a constantly fine-tuned non-thrombogenic environment. The arterial wall anatomy also serves to promote thrombosis… CONTINUE READING

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