Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.

@article{Renau2001AddressingTS,
  title={Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.},
  author={Thomas E Renau and Roger L{\'e}ger and Eric M Flamme and Miles W She and Carla L Gannon and Kristina Mathias and Olga Lomovskaya and Suzanne Chamberland and Ving J. Lee and Toshiharu Ohta and Kiyoshi Nakayama and Yohei Ishida},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 5},
  pages={
          663-7
        }
}
Synthetic optimization of a biologically labile class of dipeptides that function as efflux pump inhibitors to potentiate the antibacterial agent levofloxacin in Pseudomonas aeruginosa has led to the discovery of a related series of compounds that are completely stable in a variety of biological matrices. Other than the stability profile, the in vitro profile of the new series is essentially identical to that observed with the original one. A prototypical compound from the new series… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations