Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease.

@article{Karlawish2011AddressingTE,
  title={Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease.},
  author={Jason H. T. Karlawish},
  journal={Neurology},
  year={2011},
  volume={77 15},
  pages={
          1487-93
        }
}
Research suggests that Alzheimer disease (AD) pathophysiology begins prior to the clinical expression of the disease and that biomarker measures may provide direct evidence of this process. As a result, it may be possible to uncouple the diagnosis of AD from the clinical expression of the disease. The shifting boundaries between normal brain aging and disease present 3 challenges: 1) establishing guidelines for researchers and clinicians to safely and effectively communicate the diagnosis of… CONTINUE READING

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