Addressing the Challenges of Low Clearance in Drug Research


As a result of high-throughput ADME screening, early metabolite identification, and exploration of novel chemical entities, low-intrinsic-clearance compounds continue to increase in drug discovery portfolios. Currently available in vitro tools have limited resolution below a certain intrinsic clearance value, which can lead to overestimation of clearance… (More)
DOI: 10.1208/s12248-014-9691-7


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@article{Di2014AddressingTC, title={Addressing the Challenges of Low Clearance in Drug Research}, author={Li Di and Ronald Scott Obach}, journal={The AAPS Journal}, year={2014}, volume={17}, pages={352-357} }