Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling.

  title={Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling.},
  author={Rasheed Ivey and Mina Desai and K Green and Indrani Sinha-Hikim and Theodore C. Friedman and Amiya P. Sinha‐Hikim},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={46 8},
  • R. IveyM. Desai A. Sinha‐Hikim
  • Published 15 May 2014
  • Biology, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Smoking is a major risk factor for diabetes and cardiovascular disease and may contribute to nonalcoholic fatty liver disease (NAFLD). The health risk associated with smoking is exaggerated by obesity and is the leading causes of morbidity and mortality worldwide. We recently demonstrated that combined treatment with nicotine and a high-fat diet (HFD) triggers greater oxidative stress, activates hepatocellular apoptosis, and exacerbates HFD-induced hepatic steatosis. Given that hepatocellular… 

Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis

It is concluded that nicotine, when combined with HFD, triggers CM apoptosis through the generation of oxidative stress and inactivation of AMPK together with the activation of caspase-2-mediated intrinsic apoptotic signaling independently of FGF21 and SIRT1.

&agr;7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet–Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling

The α7nAChR agonist PNU protects against nicotine plus HFD-induced hepatic steatosis in obese mice and appears to work at various steps of signaling pathways involving suppression of oxidative stress, activation of AMPK, and inhibition of SREBP1c, FAS, and ACC.

Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect

The results indicate that the environment of high-fat diet plays an important role in the development of liver injury after prenatal stress and cellular apoptosis in prenatal glucocorticoid overexposure and a postnatal high fat diet in rats.

Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation

Results indicate that nicotine‐induced Akt ubiquitination and degradation occurs through TTC3 and MUL1 and results in a dramatic increase in apoptosis in HUVECs cultured in HG/HF media.

Agmatine protects rat liver from nicotine-induced hepatic damage via antioxidative, antiapoptotic, and antifibrotic pathways

Findings indicate that AGM could successfully overcome the nicotine-evoked hepatic oxidative stress and tissue injury, apoptosis, and fibrosis in rats.

Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice

Significant adverse effects of e-cigarettes with nicotine at doses that yield circulating nicotine and cotinine in the ranges similar to the levels found in habitual smokers, and a high fat diet on cardiac structure and function in a commonly used model of diet-induced obesity (DIO).

Expression Changes of Apoptotic Genes in Tissues from Mice Exposed to Nicotine

Insight is provided into the molecular mechanisms of nicotine anti-apoptotic effects on the heart and lung as well as pro-APoptotic effect on kidney and liver via a P53-independent pathway.

Oil emulsion from Plukenetia huayllabambana (Sacha inchi) modifies nitric oxide and leptin in the liver and antioxidant and inflammation markers in the adipose tissue in obese rats

It is suggested that the emulsion of SI oil can modify the inflammatory and stress responses associated with obesity and it can be incorporated as a promising functional food.

Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury

  • Hui LiuQian Li Shulong Yang
  • Biology, Medicine
    Hepatology research : the official journal of the Japan Society of Hepatology
  • 2017
The newest research progress in the relationships between higher NO levels and hepatic cell apoptosis in liver injury is reviewed.

Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

The contribution of nicotine, poor dietary choices and other unhealthy lifestyle factors to gut dysbiosis is explored.