Additive effects of glyburide and antidepressants in the forced swimming test: Evidence for the involvement of potassium channel blockade

@article{Guo1996AdditiveEO,
  title={Additive effects of glyburide and antidepressants in the forced swimming test: Evidence for the involvement of potassium channel blockade},
  author={Wenyu Guo and K. Todd and Michel Bourin and Martine Hascoet and Faustin Kouadio},
  journal={Pharmacology Biochemistry and Behavior},
  year={1996},
  volume={54},
  pages={725-730}
}
Evidence in the literature suggests that the modulatory effects of antidepressant drugs (ADS) on neuronal excitability, via the inhibition of K+ channels, may be the final common pathway of pharmacological action. Therefore, we tested the hypothesis that combining the ATP-sensitive K+ channel blocker glyburide with a variety of ADS would produce an additive effect and decrease the immobility time of mice in the forced swimming test (FST). Glyburide (GLY, IP, 30 and 50 mg/kg) and subactive doses… Expand
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