Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeletal sites in an aged rat model.

@article{Mosekilde1999AdditiveEO,
  title={Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeletal sites in an aged rat model.},
  author={Leif Mosekilde and Jesper Skovhus Thomsen and P. B. Orhii and Robert J. McCarter and Walter Mejia and Dike N. Kalu},
  journal={Bone},
  year={1999},
  volume={24 2},
  pages={71-80}
}
The aim of the study was to assess the effect of growth hormone (GH), voluntary exercise (Ex), and the combination of GH and Ex on bone strength, mass, and dimensions in aged, intact female rats. In addition, the effect of food restriction (FR) was studied. Fourteen-month-old virgin F-344 rats were divided into 6 groups with 13 animals in each: (1) baseline (BSL); (2) control + solvent vehicle (CTRL); (3) GH 2.5 mg/kg/day (GH); (4) exercise, voluntary: 0.6-0.7 km/day (Ex); (5) GH treatment and… CONTINUE READING