Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms.

Abstract

Stress and exposure to drug-related environmental stimuli have been implicated as critical factors in relapse to drug use. What has received little attention, however, is the significance of interactions between these factors for motivating drug-seeking behavior. To address this issue, a reinstatement model of relapse was used. Footshock stress and response… (More)

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@article{Liu2002AdditiveEO, title={Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms.}, author={Xiu Liu and Friedbert Weiss}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2002}, volume={22 18}, pages={7856-61} }