Additive effect of betaxolol and epinephrine in primary open angle glaucoma.

@article{Allen1986AdditiveEO,
  title={Additive effect of betaxolol and epinephrine in primary open angle glaucoma.},
  author={Robert C. Allen and David Lee Epstein},
  journal={Archives of ophthalmology},
  year={1986},
  volume={104 8},
  pages={
          1178-84
        }
}
Betaxolol hydrochloride is a topical beta 1-blocking agent that has been found to be safe and effective in lowering intraocular pressure (IOP) in patients with glaucoma. We administered open-label epinephrine for four weeks to 19 patients who were already being treated with masked 0.5% timolol maleate or 0.5% betaxolol. In patients receiving betaxolol, epinephrine produced a significant additional lowering of mean IOP from 24.5 +/- 0.7 to 19.4 +/- 0.6 mm Hg at one week (P less than .0001) and… 
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TLDR
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TLDR
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Betaxolol appears to be a clinically effective and safe agent in the treatment of open-angle glaucoma, however, the magnitude of the decrease in intraocular pressure with it may not be as great as that with timolol and there may be a greater need for adjunctive therapy with it than with Timolol.
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TLDR
The action and interaction of topical 2% epinephrine hydrochloride and 0.5% timolol maleate therapy were studied in normal and ocular hypertensive subjects and the effects in lowering IOP may not be completely additive.
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A randomized, double-blind clinical study was conducted on patients with primary open angle glaucoma to determine whether timolol and epinephrine have an additive effect in lowering intraocular pressure and possible fundamental beta- and alpha-adrenergic influences on aqueous dynamics are discussed.
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TLDR
There was an initial enhancement of pressure reduction when epinephrine was added to timolol in both sequences, and this additive effect was still present after three months of combined therapy.
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The clinical usefulness of concurrent administration of betaxolol and acetazolamide to lower intraocular pressure is supported, and the drug should be added to the therapy regimen of a patient already receiving topical betxolol.
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TLDR
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