Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.

  title={Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.},
  author={Alasdair J. Leslie and Philippa C Matthews and Jennifer Listgarten and Jonathan M. Carlson and Carl M. Kadie and Thumbi Ndung'u and Christian Brander and Hoosen Mahomed Coovadia and Bruce D. Walker and David Heckerman and Philip J. R. Goulder},
  journal={Journal of virology},
  volume={84 19},
Previous studies have identified a central role for HLA-B alleles in influencing control of HIV infection. An alternative possibility is that a small number of HLA-B alleles may have a very strong impact on HIV disease outcome, dominating the contribution of other HLA alleles. Here, we find that even following the exclusion of subjects expressing any of the HLA-B class I alleles (B*57, B*58, and B*18) identified to have the strongest influence on control, the dominant impact of HLA-B alleles on… CONTINUE READING


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