Additive antiviral effects of lamivudine and alpha-interferon in chronic hepatitis B infection.

@article{Mutimer2000AdditiveAE,
  title={Additive antiviral effects of lamivudine and alpha-interferon in chronic hepatitis B infection.},
  author={David John Mutimer and D. Dowling and Patricia A. Cane and Daina Ratcliffe and Hong Tang and Katrina M O'Donnell and Jean Shaw and Elwyn E Elias and Deenan Pillay},
  journal={Antiviral therapy},
  year={2000},
  volume={5 4},
  pages={273-7}
}
alpha-Interferon has limited efficacy against chronic hepatitis B virus (HBV) infection. Nucleoside analogues may confer greater benefits, however, it is likely that combination therapies will be required for effective control of this infection. We investigated the antiviral effect of lamivudine and interferon therapy in eight patients with high HBV-DNA levels. Six patients received lamivudine/interferon combination therapy followed, after a 6-month drug-free period, with lamivudine monotherapy… CONTINUE READING
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