Additive Effects of Zinc Chloride on the Suppression of Hepatitis A Virus Replication by Interferon in Human Hepatoma Huh7 Cells

  title={Additive Effects of Zinc Chloride on the Suppression of Hepatitis A Virus Replication by Interferon in Human Hepatoma Huh7 Cells},
  author={Tatsuo Kanda and Reina Sasaki and Ryota Masuzaki and Hiroshi Takahashi and Mariko Fujisawa and Naoki Matsumoto and Hiroaki Okamoto and Mitsuhiko Moriyama},
  journal={In Vivo},
  pages={3301 - 3308}
Background/Aim: Hepatitis A virus (HAV) infection is still one of the serious health problems worldwide, despite the existence of effective vaccines for HAV. Zinc compounds have antiviral activities against various DNA and RNA viruses. Therefore, we investigated the effects of zinc compounds on the antiviral activity of interferon against HAV. Materials and Methods: The effects of zinc compounds with or without interferon on HAV genotype IIIA HA11-1299 replication were examined in human… Expand
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