Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29.

Abstract

After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

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Cite this paper

@article{Schosser2007AdditionalSF, title={Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29.}, author={Alexandra Schosser and Karoline Fuchs and Theresa Scharl and Friedrich Leisch and Ursula F. Bailer and Siegfried Kasper and Werner Sieghart and Kurt Hornik and Harald Nikolaus Aschauer}, journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, year={2007}, volume={17 6-7}, pages={501-5} }