Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia.

@article{Sijbrands2000AdditionalRF,
  title={Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia.},
  author={Eric J G Sijbrands and Rudi G. J. Westendorp and M Paola Lombardi and Louis M. Havekes and Rune R. Frants and John J. P. Kastelein and August H M Smelt},
  journal={Atherosclerosis},
  year={2000},
  volume={149 2},
  pages={
          421-5
        }
}
Life expectancy of patients with familial hypercholesterolaemia is decreased. Some untreated patients reach a normal life span and, therefore, additional risk factors and the type of mutation in the low-density lipoprotein (LDL) receptor gene are likely to influence the clinical outcome. We determined all cause mortality in kindreds with the disorder, who were untreated, in order to study (a) additional risk factors for coronary artery disease (CAD) and (b) the types of LDL receptor gene… CONTINUE READING
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