Additional evidence that l-5-hydroxytryptophan discrimination models a unique serotonin receptor

  title={Additional evidence that l-5-hydroxytryptophan discrimination models a unique serotonin receptor},
  author={Roberta L. Friedman and R. Barrett and E. sanders-Bush},
  • Roberta L. Friedman, R. Barrett, E. sanders-Bush
  • Published 2004
  • Psychology, Medicine
  • Psychopharmacology
  • The purpose of the present studies was to investigate further the role of central serotonin (5-HT) in mediating the l-5-hydroxytryptophan (l-5-HTP) discriminative cue. Rats were trained to discriminate the stimulus properties of 35 mg/kg l-5-HTP combined with RO 4-4602, a peripheral decarboxylase inhibitor. Considering that several 5-HT antagonists were unable to block the l-5-HTP discriminative cue in our earlier studies, we extended these studies to include the two other presumed 5-HT… CONTINUE READING
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