Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man

@article{Schmitt2002AdditionalDR,
  title={Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man},
  author={Jeroen A. J. Schmitt and Johannes G Ramaekers and Monique J. Kruizinga and Martin P.J. van Boxtel and E. F. P. M. Vuurman and Wim J. Riedel},
  journal={Journal of Psychopharmacology},
  year={2002},
  volume={16},
  pages={207 - 214}
}
There is evidence for a specific impairment of human vigilance following enhancement of serotonergic activity by antidepressant drugs. In the present study, we investigated the putative role of serotonergic–dopaminergic interactions in diminished vigilance by comparing the attentional effects of sertraline, a selective serotonin reuptake inhibitor (SSRI) with additional mild dopamine stimulating effects, with those of paroxetine, a SSRI without dopamine activity, using a placebo-controlled… 
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References

SHOWING 1-10 OF 53 REFERENCES
Involvement of serotonin and dopamine in the mechanism of action of novel antidepressant drugs: a review.
TLDR
Analysis of the current literature indicates that long-term treatment with antidepressants causes adaptive changes of the serotonergic and dopaminergic systems, and this article reports studies reporting the biochemical, behavioral, and clinical effects of tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and antagonists of serotonin-2 receptors.
Venlafaxine's effects on healthy volunteers' driving, psychomotor, and vigilance performance during 15-day fixed and incremental dosing regimens.
Effects of venlafaxine, an antidepressant acting by selective serotonin and norepinephrine reuptake inhibition with a potency ratio of 5:1, were assessed in a standardized, actual driving test, a
Cognitive and Psychomotor Effects of Antidepressants with Emphasis on Selective Serotonin Reuptake Inhibitors and the Depressed Elderly Patient
TLDR
There is a need for well designed comparative studies to characterize the differential cognitive profiles of SSRIs and other newer antidepressants, and more importantly to show the clinical relevance, if any, of these differences.
Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
  • J. Hyttel
  • Psychology, Biology
    International clinical psychopharmacology
  • 1994
TLDR
Since the marketed SSRIs all show clear antidepressant effect, this receptor regulation seems not to be a prerequisite for clinical antidepressant activity.
Selective serotonin reuptake inhibitors in affective disorders -II. Efficacy and quality of life
TLDR
The relative quantity and quality of data on fluoxetine and sertraline means that it is possible to make relatively firm inferences regarding their differential effects on affective symptoms andquality of life.
Serotonin-dopamine interaction and its relevance to schizophrenia.
TLDR
Serotonergic modulation of dopaminergic function provides a viable mechanism for enhancing therapeutics in schizophrenia, but much remains unclear.
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
TLDR
Results indicate that serotonin is essential in the process of long-term memory consolidation, primarily in the first 30 min after acquisition, and that improvement of specific cognitive processes by lowered 5-HT function may be linked to the removal of inhibitory actions of 5- HT in the cortex.
Extrapyramidal Symptoms Associated with Selective Serotonin Reuptake Inhibitors
TLDR
Anatomical, physiological and pharmacological relationships between SSRI-induced movement disorders includes avoidance of SSRI use, dose reduction or discontinuation of the offending drug and the same measures that are used for treating antipsychotic- induced movement disorders.
A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance.
TLDR
Neither drug significantly affected driving performance while receiving dothiepin or fluoxetine in a double-blind, cross-over study involving 18 healthy volunteers.
...
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