Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man

  title={Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man},
  author={Jeroen A. J. Schmitt and Johannes G Ramaekers and Monique J. Kruizinga and Martin P.J. van Boxtel and E. F. P. M. Vuurman and Wim J. Riedel},
  journal={Journal of Psychopharmacology},
  pages={207 - 214}
There is evidence for a specific impairment of human vigilance following enhancement of serotonergic activity by antidepressant drugs. In the present study, we investigated the putative role of serotonergic–dopaminergic interactions in diminished vigilance by comparing the attentional effects of sertraline, a selective serotonin reuptake inhibitor (SSRI) with additional mild dopamine stimulating effects, with those of paroxetine, a SSRI without dopamine activity, using a placebo-controlled… 
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  • J. Hyttel
  • Psychology, Biology
    International clinical psychopharmacology
  • 1994
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