Additional cytogenetic abnormalities in adults with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a study of the Cancer and Leukaemia Group B.

@article{Wetzler2004AdditionalCA,
  title={Additional cytogenetic abnormalities in adults with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a study of the Cancer and Leukaemia Group B.},
  author={Meir Wetzler and Richard K. Dodge and Krzysztof Mr{\'o}zek and Carleton C. Stewart and Andrew J. Carroll and Ramana Tantravahi and James W. Vardiman and Richard A Larson and Clara D. Bloomfield},
  journal={British journal of haematology},
  year={2004},
  volume={124 3},
  pages={275-88}
}
We analysed the nature and prognostic significance of secondary cytogenetic changes in 111 newly diagnosed adults with acute lymphoblastic leukaemia (ALL) and t(9;22)(q34;q11.2) or its variants. Secondary aberrations were seen in 75 (68%) patients. They included, in order of descending frequency: +der(22)t(9;22), +21, abnormalities of 9p, high hyperdiploidy (>50 chromosomes), +8, -7, +X and abnormalities resulting in loss of material from 8p, gain of 8q, gain of 1q and loss of 7p. Eighty… CONTINUE READING