Additional chromosomal abnormalities and variability of BCR breakpoints in Philadelphia chromosome/BCR-ABL-positive acute lymphoblastic leukemia in Taiwan.

@article{Ko2002AdditionalCA,
  title={Additional chromosomal abnormalities and variability of BCR breakpoints in Philadelphia chromosome/BCR-ABL-positive acute lymphoblastic leukemia in Taiwan.},
  author={Bor-Sheng Ko and J Tang and F Lee and Ming-Chi Liu and Woei Tsai and Yao-Chang Chen and C Wang and Ming-Chin Sheng and Dong-Tsam Lin and Kai-Hsin Lin and H. -F. Tien},
  journal={American journal of hematology},
  year={2002},
  volume={71 4},
  pages={291-9}
}
From 1986 to 1998, 26 (23%) of 114 adult acute lymphoblastic leukemia (ALL) patients and 11 (4%) of 328 pediatric patients were found to have Philadelphia (Ph) chromosome. In the 30 patients with available data at diagnosis, 18 (60%) had extra-chromosomal abnormalities. They included 1q duplication (5/18, 28%), supernumerary Ph chromosome (4/18, 22%), 9p abnormalities (3/18, 17%), 7q deletion/monosomy 7 (3/18, 17%), trisomy 19 (1/18, 6%), and trisomy 8 (1/18, 6%). Excluding those with specific… CONTINUE READING

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