Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo.

@article{Sakai1992AdditionalAE,
  title={Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo.},
  author={Ryoji Sakai and Kenneth L. Rinehart and Yongbiao Guan and Andrew H.-J. Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 23},
  pages={11456-60}
}
Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of… CONTINUE READING