Additional Transaminations by Insoluble Particle Preparations of Rat Liver

@article{Hird1950AdditionalTB,
  title={Additional Transaminations by Insoluble Particle Preparations of Rat Liver},
  author={F. Hird and E. Rowsell},
  journal={Nature},
  year={1950},
  volume={166},
  pages={517-518}
}
Braunstein and Kritzmann1 suggested that transamination in pigeon breast muscle was a general reaction involving most of the amino-acids; Cohen2 was unable to confirm these results, and pointed out the lack of experimental controls. Further work by Cohen3 with purified enzyme preparations suggested that the transamination reactions were limited to L-glutamate + oxalacetate \[rlharr] α-ketoglutarate + L-aspartate and L-glutamate + pyruvate \[rlharr] α-ketoglutarate + L-alanine. Slower but… Expand
55 Citations
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It will be shown that the cell nucleus contains significant transaminase activities, mostly localized in the nuclear sap, resolvable by chromatography. Expand
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The results give evidence for mitochondrial l -glutamic dehydrogenase and transaminase as a functional cyclic system in the deamination of amino acids and as mediators of the oxidation of their carbon skeletons. Expand
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Homogenates of fat-body of Schistocerca gregaria Forsk were shown to catalyse transamination reactions between α-ketoglutarate and numerous α-amino acids, and it appears that amino-acid metabolism in the locust resembles that in higher animals. Expand
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This review outlines the events leading to the discovery of enzymatic transamination, how the discovery was made, the findings that led to the recognition by the mid-1950s of the very wide scope and biological importance of aminotransferase reactions, and the elucidation of the primary amino acid sequence and three-dimensional structure of aspartate aminotsferases. Expand
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  • Chemistry, Medicine
  • Journal of general microbiology
  • 1963
TLDR
Various transamination reactions were observed in germinating uredospores of Puccinia helianthi Schw and the presence of glutamate-aspartate transaminase enzymes in the u redospores suggests that the uredosphere could synthesize a large number of amino acids. Expand
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TLDR
Mitochondria prepared from mouse and rat tumours with isotonic sucrose containing ethylene diaminetetracetate (versene) were found to demonstrate triphosphopyridine nucleotide-splitting activity, which was characterized as a nicotinamide- and iso nicotinyl hydrazide-sensitive nucleosidase. Expand
Increased rat liver homogenate, mitochondrial, and cytosolic aspartate aminotransferase activity in acute carbon tetrachloride poisoning.
  • N. J. Pappas
  • Biology, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 1980
TLDR
The hypothesis that increased synthesis may be a source of increased serum aspartate aminotransferase and its isoenzymes as a response to hepatocellular injury is supported. Expand
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References

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TRANSAMINATION WITH PURIFIED ENZYME PREPARATIONS (TRANSAMINASE)
TLDR
The author found that transamination in pigeon breast muscle is limited to the following reactions. Expand
Transamination and the integrative functions of the dicarboxylic acids in nitrogen metabolism.
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  • Chemistry, Medicine
  • Advances in protein chemistry
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TLDR
The conception of the dicarboxylic acid system as a central component of first order in the chemical integration of nitrogenous metabolism satisfactorily accounts for the widespread occurrence of transamination and for its exceptionally high activity in certain tissues. Expand
The utilization of some phenylpyruvic acids for growth in the rat.
Transamination in pigeon breast muscle.
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