Addition of valproic acid to CHO cell fed-batch cultures improves monoclonal antibody titers.

@article{Yang2014AdditionOV,
  title={Addition of valproic acid to CHO cell fed-batch cultures improves monoclonal antibody titers.},
  author={William C Yang and Jiuyi Lu and Ngan Nguyen and An Yun Zhang and Nicholas V Healy and Rashmi Kshirsagar and Thomas Ryll and Yao-ming Huang},
  journal={Molecular biotechnology},
  year={2014},
  volume={56 5},
  pages={
          421-8
        }
}
Improving the productivity of a biopharmaceutical Chinese hamster ovary (CHO) fed-batch cell culture can enable cost savings and more efficient manufacturing capacity utilization. One method for increasing CHO cell productivity is the addition of histone deacetylase (HDAC) inhibitors to the cell culture process. In this study, we examined the effect of valproic acid (VPA, 2-propylpentanoic acid), a branched-chain carboxylic acid HDAC inhibitor, on the productivity of three of our CHO cell lines… CONTINUE READING

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