Addition of metronidazole to azathioprine for the prevention of postoperative recurrence of Crohn's disease: a randomized, double-blind, placebo-controlled trial.

@article{Maosa2013AdditionOM,
  title={Addition of metronidazole to azathioprine for the prevention of postoperative recurrence of Crohn's disease: a randomized, double-blind, placebo-controlled trial.},
  author={M{\'i}riam Ma{\~n}osa and Eduard Cabr{\'e} and Isabel Bernal and Mar{\'i}a Carmen Guixeres Esteve and Esther Garc{\'i}a-Planella and Elena Ricart and Mireia Pe{\~n}alva and Xavier Cort{\'e}s and J. S. Giner Boix and M Ba{\~n}uelos Pi{\~n}ol and Miquel Angel Gassull and Eugeni Dom{\'e}nech},
  journal={Inflammatory bowel diseases},
  year={2013},
  volume={19 9},
  pages={
          1889-95
        }
}
BACKGROUND Endoscopic recurrence occurs in up to 80% of patients with Crohn's disease 1 year after intestinal resection. Imidazole antibiotics, thiopurines, and particularly their combination have proven efficacy in preventing endoscopic recurrence. The aim of the study was to compare the efficacy of the addition of metronidazole (for 3 months after the surgical treatment) to azathioprine for the prevention of postsurgical endoscopic recurrence. METHODS A pilot study was made of 50 patients… CONTINUE READING
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