Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trial.

@article{Szegedi1999AdditionOL,
  title={Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trial.},
  author={Armin Szegedi and Ion G Anghelescu and Jason Wiesner and Sabine Schlegel and Harald Weigmann and Sebastian Haertter and Christoph Hiemke and Hermann Wetzel},
  journal={Pharmacopsychiatry},
  year={1999},
  volume={32 4},
  pages={148-53}
}
Combining fluvoxamine and clozapine may be a strategy to improve therapeutic effects on negative symptoms in schizophrenic patients. Fluvoxamine, however, markedly inhibits the metabolism of clozapine, and hazardous side effects may result. This study prospectively investigated the safety and tolerability of an add-on therapy with fluvoxamine to a clozapine monotherapy in schizophrenic patients. Sixteen schizophrenic patients received 50 mg fluvoxamine as a comedication after having reached… CONTINUE READING