Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering.

@article{Matsiko2012AdditionOH,
  title={Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering.},
  author={Amos Matsiko and Tanya J. Levingstone and Fergal J O'Brien and John P. Gleeson},
  journal={Journal of the mechanical behavior of biomedical materials},
  year={2012},
  volume={11},
  pages={41-52}
}
The response of mesenchymal stem cells (MSCs) to a matrix largely depends on the composition as well as the extrinsic mechanical and morphological properties of the substrate to which they adhere to. Collagen-glycosaminoglycan (CG) scaffolds have been extensively used in a range of tissue engineering applications with great success. This is due in part to the presence of the glycosaminoglycans (GAGs) in complementing the biofunctionality of collagen. In this context, the overall goal of this… CONTINUE READING

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