Addition of human melanopsin renders mammalian cells photoresponsive

@article{Melyan2005AdditionOH,
  title={Addition of human melanopsin renders mammalian cells photoresponsive},
  author={Zare Melyan and Emma E. Tarttelin and James Bellingham and Robert J. Lucas and M. W. Hankins},
  journal={Nature},
  year={2005},
  volume={433},
  pages={741-745}
}
A small number of mammalian retinal ganglion cells act as photoreceptors for regulating certain non-image forming photoresponses. These intrinsically photosensitive retinal ganglion cells express the putative photopigment melanopsin. Ablation of the melanopsin gene renders these cells insensitive to light; however, the precise role of melanopsin in supporting cellular photosensitivity is unconfirmed. Here we show that heterologous expression of human melanopsin in a mouse paraneuronal cell line… Expand
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  • Proceedings of the National Academy of Sciences
  • 2006
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