Addition of dioxygen to an N4S(thiolate) iron(II) cysteine dioxygenase model gives a structurally characterized sulfinato-iron(II) complex.


The non-heme iron enzyme cysteine dioxygenase (CDO) catalyzes the S-oxygenation of cysteine by O(2) to give cysteine sulfinic acid. The synthesis of a new structural and functional model of the cysteine-bound CDO active site, [Fe(II)(N3PyS)(CH(3)CN)]BF(4) (1) is reported. This complex was prepared with a new facially chelating 4N/1S(thiolate) pentadentate… (More)
DOI: 10.1021/ja302112y


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