Addition of diethylzinc to dicobalt hexacarbonyl complexes of alpha,beta-acetylenic aldehydes with virtually complete enantioselectivity. A formal synthesis of (+)-incrustoporin.

@article{Fontes2002AdditionOD,
  title={Addition of diethylzinc to dicobalt hexacarbonyl complexes of alpha,beta-acetylenic aldehydes with virtually complete enantioselectivity. A formal synthesis of (+)-incrustoporin.},
  author={Montserrat Fontes and Xavier Verdaguer and Llu{\'i}s Sol{\`a} and Anton Vidal-Ferran and Katamreddy Subba Reddy and Antoni Riera and Miquel {\`A} Peric{\`a}s},
  journal={Organic letters},
  year={2002},
  volume={4 14},
  pages={2381-3}
}
[reaction: see text] The addition of diethylzinc to dicobalt hexacarbonyl complexes of acetylenes mediated by (R)-2-piperidino-1,1,2-triphenylethanol takes place with very high enantioselectivity (96-99% ee) to afford the S enantiomers of dicobalt hexacarbonyl complexes of 1-alkynyl-1-propanols. The utility of this process is exemplified by the development… CONTINUE READING