Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis.

@article{Graybill2003AdditionOC,
  title={Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis.},
  author={John Richard Graybill and R. Castillo Bocanegra and Laura K. Najvar and Steve A. Hernandez and Robert A. Larsen},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 7},
  pages={2373-5}
}
Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.