Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.

  title={Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.},
  author={Rury R Holman and Kerensa I Thorne and Andrew D. Farmer and Melanie J Davies and Joanne F Keenan and Sanjoy K Paul and Jonathan Cummings Levy},
  journal={The New England journal of medicine},
  volume={357 17},
BACKGROUND Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited. METHODS In an open-label, controlled, multicenter trial, we randomly assigned 708 patients with a suboptimal glycated hemoglobin level (7.0 to 10.0%) who were receiving maximally tolerated doses of metformin and sulfonylurea to receive biphasic insulin aspart twice daily, prandial insulin aspart three times… CONTINUE READING
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